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Drug class

Biguanide medications

“Biguanide” is a drug class recorded for these medicines in the National Library of Medicine’s RxClass service — usually the FDA “established pharmacologic class” from the drug label, which groups medicines by how they work or what they are. Our directory includes 4 medicines in this class, 3 of which carry a boxed warning on the label shown.
  • Metformin

    Brand names: Glucophage, Glumetza, Riomet

    The label says: Metformin hydrochloride oral solution is indicated as an adjunct to diet and exercise to improve glycemic control in adults and pediatric patients 10 years of age and older with type 2 diabetes mellitus. …

    UsesWhat it looks likeWarnings (boxed)

  • Metformin and sitagliptin

    Brand names: Janumet, Zituvimet

    The label says: ZITUVIMET is a combination of sitagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, and metformin hydrochloride (HCl), a biguanide, indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. …

    UsesWhat it looks likeWarnings (boxed)

  • Glipizide and metformin

    The label says: Glipizide and metformin hydrochloride tablets, USP are indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

    UsesWhat it looks likeWarnings

  • Empagliflozin and metformin

    Brand names: Synjardy

    The label says: SYNJARDY SYNJARDY is a combination of empagliflozin, a sodium-glucose co-transporter 2 (SGLT2) inhibitor and metformin hydrochloride (HCl) immediate-release, a biguanide, indicated as an adjunct to diet and exercise to improve glycemic control in adults and pediatric patients aged 10 years and older …

    UsesWhat it looks likeWarnings (boxed)

Medicines in the same class can still differ in their approved uses, warnings and side effects. Class membership comes from the FDA label data published through the National Library of Medicine's RxClass service.

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